Progressive adipocyte hypertrophy
WebNational Center for Biotechnology Information WebJul 5, 2024 · This study evaluates the progressive participation of enzymes involved in lipolysis and lipogenesis, leading to adipocyte hypertrophy in a metabolic syndrome (MS) rat model caused by chronic...
Progressive adipocyte hypertrophy
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WebJul 5, 2024 · This study evaluates the progressive participation of enzymes involved in lipolysis and lipogenesis, leading to adipocyte hypertrophy in a metabolic syndrome (MS) … For CLS induction, we used an established tissue culture model19. After sacrifice, the rostral part of the epididymal white adipose tissue (EWAT) was dissected and cut into small pieces of <1 mm³ (AT explants) under sterile conditions at 37 °C in PBS. AT explants were then transferred to six-well plates filled with 1 ml … See more Animal experiments followed the ‘Principles of laboratory animal care’ (NIH publication no. 85e23, revised 1985) as well as specific national laws approved by the … See more Live-imaging was performed on AT explants of HFD-fed MacGreen mice stained with 1 µg/ml BODIPY 558/568 C12 (Life Technologies GmbH, Darmstadt, Germany) … See more Laser-injury of individual adipocytes was performed on AT explants of chow-fed mice without pre-established AT inflammation. After the 72 h of cultivation, … See more Antibody staining was performed on AT whole mounts and AT explants after live-imaging. Of note, AT explants were immobilized on the cell culture inserts by adding … See more
WebNational Center for Biotechnology Information WebJun 1, 2008 · Adipocyte hypertrophy, evident in both overweight and type 2 diabetes patients ( 7 ), was originally considered the sole route whereby adipose tissue mass increased in adults. However, adipocyte hyperplasia (adipogenesis) is now known to contribute to the increased adipose tissue mass of obesity.
WebMar 22, 2024 · Adipose tissue inflammation has been suggested to play a central role in the pathogenesis of many obesity-associated complications including insulin resistance and type 2 diabetes. Adipocyte hypertrophy and hypoxia especially in morbid obesity are the important sources for the development of adipose tissue inflammation. This … WebMar 3, 2005 · In contrast, at age 4 weeks, adipocyte volume and body fat mass were comparable in wild type and AQP7 null mice. To investigate the mechanism(s) responsible for the progressive adipocyte hypertrophy, glycerol permeability and fat metabolism were studied in adipocytes isolated from the younger mice.
WebAug 1, 2005 · Accumulation of excess brain water (brain edema) is a major cause of mortality and morbidity in stroke and in brain tumor, trauma and infection. `Cytotoxic' or cellular brain edema results from excessive movement of water into the brain across an intact BBB, producing an expanded intracellular space. `Vasogenic' or leaky-vessel brain …
WebNov 29, 2024 · Obesity is characterized by increased adipose tissue mass resulting from both an increase in size of individual adipocytes and the generation of new adipocytes [].Adipocytes are made up of more than 95% triacylglycerols (TAGs) that are hydrolyzed to fatty acids and glycerol during lipolysis [].Glycerol plays a major role in energy … takko kranjWebProgressive Adipocyte Hypertrophy in Aquaporin-7-deficient Mice Previous Article Mad1 Function in Cell Proliferation and Transcriptional Repression Is Antagonized by Cyclin … bastandard bathroom dimsWebFeb 3, 2024 · Obesity-induced adipocyte hypertrophy and progressive adipose tissue dysfunction induce insulin resistance and metabolic inflexibility characterised by increased leakage of FFAs, leading to increased pro-inflammatory cytokines and aberrant adipokine patterns, further aggravating adipose tissue dysfunction. basta na terasiWebProgressive Adipocyte Hypertrophy in Aquaporin-7-deficient Mice ADIPOCYTE GLYCEROL PERMEABILITY AS A NOVEL REGULATOR OF FAT ACCUMULATION* Received for publication, January 21, 2005, ba standard baggage allowanceWebOct 6, 2024 · On the one hand, adipocyte hypertrophy triggers inflammatory response and exacerbates regional hypoxia, further making excessive collagen deposition. On the other hand, pathophysiological changes subsequently contribute to dysregulation of adipokine release and impaired glucose metabolism. ba standard luggage allowanceWebJul 1, 2011 · AQP7 is expressed in the plasma membrane of adipocytes. Aqp7 -null mice manifest a remarkable progressive increase in fat mass and adipocyte hypertrophy, accumulating glycerol and triglycerides in their adipocytes, as they age ( Hara-Chikuma et al., 2005; Hibuse et al., 2005 ). bastandoWebJan 4, 2024 · Adipose tissue can increase in size in one of two main ways: hypertrophy (increase in size of existing adipocytes) or hyperplasia (formation of new adipocytes through differentiation of resident ... bastanahrad